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A novel method for measuring the bending rigidity of model lipid membranes by simulating tethers

机译:通过模拟系链测量模型脂质膜弯曲刚度的新方法

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摘要

The tensile force along a cylindrical lipid bilayer tube is proportional to the membrane’s bending modulus and inversely proportional to the tube radius. We show that this relation, which is experimentally exploited to measure bending rigidities, can be applied with even greater ease in computer simulations. Using a coarse-grained bilayer model we efficiently obtain bending rigidities that compare very well with complementary measurements based on an analysis of thermal undulation modes. We furthermore illustrate that no deviations from simple quadratic continuum theory occur up to a radius of curvature comparable to the bilayer thickness.
机译:沿着圆柱形脂质双层管的张力与膜的弯曲模量成正比,与管半径成反比。我们表明,这种关系已被实验用来测量弯曲刚度,可以在计算机仿真中更加轻松地应用。使用粗粒度双层模型,我们可以有效地获得弯曲刚度,该弯曲刚度可以根据热波动模式的分析与互补测量进行很好的比较。我们进一步说明,直到与双层厚度可比的曲率半径,都没有发生与简单二次连续理论的偏差。

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